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Generic Name: dulaglutide injection, for subcutaneous use
Brand Name: Trulicity
Drug Class: Antidiabetics, Glucagon-like Peptide-1 Agonists
Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 10/13/2021
HOME DRUGS A-Z LIST SIDE EFFECTS DRUG CENTER TRULICITY (DULAGLUTIDE INJECTION, FOR SUBCUTANEOUS USE) DRUG
What is Trulicity and how is it used?
Trulicity is a prescription medicine used to treat the symptoms of Diabetes Melltus Type 2. It may be used alone or with other medications.
Trulicity belongs to a class of drugs called Antidiabetics, Glucagon-like Peptide-1 Agonists.
It is not known if Trulicity is safe and effective in children.
What are the possible side effects of Trulicity?
Trulicity may cause serious side effects including:
severe pain in your upper stomach, spreading to your back,
swelling or a lump in your neck,
a horse voice,
shortness of breath,
fast heart rate,
little or no urination,
swelling of your feet or ankles, and
Get medical help right away, if you have any of the symptoms listed above.
The most common side effects of Trulicity include:
loss of appetite
Tell the doctor if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Trulicity. For more information, ask your doctor or pharmacist.
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TRULICITY contains dulaglutide, a human GLP-1 receptor agonist. The molecule is a fusion protein that consists of 2 identical, disulfide-linked chains, each containing an N-terminal GLP-1 analog sequence covalently linked to the Fc portion of a modified human immunoglobulin G4 (IgG4) heavy chain by a small peptide linker and is produced using mammalian cell culture. The GLP-1 analog portion of dulaglutide is 90% homologous to native human GLP-1 (7-37). Structural modifications were introduced in the GLP-1 part of the molecule responsible for interaction with the enzyme dipeptidyl-peptidase-IV (DPP-4).
Additional modifications were made in an area with a potential T-cell epitope and in the areas of the IgG4 Fc part of the molecule responsible for binding the high-affinity Fc receptors and half-antibody formation. The overall molecular weight of dulaglutide is approximately 63 kilodaltons.
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TRULICITY is a clear, colorless, sterile solution. Each 0.5 mL of TRULICITY solution contains 0.75 mg or 1.5 mg of dulaglutide. Each single-dose pen contains 0.5 mL of solution and the following excipients: citric acid anhydrous (0.07 mg), mannitol (23.2 mg), polysorbate 80 (0.10 mg), trisodium citrate dihydrate (1.37 mg), in water for injection. Buy Trulicity Dulaglutide Diabetes Injection
DOSAGE AND ADMINISTRATION
The recommended initiating dose of TRULICITY is 0.75 mg once weekly. The dose may be increased to 1.5 mg once weekly for additional glycemic control. The maximum recommended dose is 1.5 mg once weekly.
Administer TRULICITY once weekly, any time of day, with or without food. TRULICITY should be injected subcutaneously in the abdomen, thigh, or upper arm.
If a dose is missed, instruct patients to administer as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose. If less than 3 days remain before the next scheduled dose, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once weekly dosing schedule.
The day of weekly administration can be changed if necessary as long as the last dose was administered 3 or more days before.
Concomitant Use With An Insulin Secretagogue (E.g., Sulfonylurea) Or With Insulin
When initiating TRULICITY, consider reducing the dosage of concomitantly administered insulin secretagogues (e.g., sulfonylureas) or insulin to reduce the risk of hypoglycemia [see WARNINGS AND PRECAUTIONS].
Important Administration Instructions
Prior to initiation of TRULICITY, patients should be trained by their healthcare professional on proper injection technique. Training reduces the risk of administration errors such as improper injection site, needle sticks, and incomplete dosing. Refer to the accompanying Instructions for Use for complete administration instructions with illustrations. The instructions can also be found at www.trulicity.com.
When using TRULICITY with insulin, instruct patients to administer as separate injections and to never mix the products. It is acceptable to inject TRULICITY and insulin in the same body region but the injections should not be adjacent to each other.
When injecting in the same body region, advise patients to use a different injection site each week. TRULICITY must not be administered intravenously or intramuscularly. TRULICITY solution should be visually inspected for particulate matter and discoloration prior to administration.
Dosage Forms And Strengths
Injection: 0.75 mg/0.5 mL solution in a single-dose pen
Injection: 1.5 mg/0.5 mL solution in a single-dose pen
Each TRULICITY single-dose pen is packaged in a cardboard outer carton.
Carton Of 4 Single-Dose Pens
0.75 mg/0.5 mL solution in a single-dose pen (NDC 0002-1433-80)
1.5 mg/0.5 mL solution in a single-dose pen (NDC 0002-1434-80)
Storage And Handling
Store TRULICITY in the refrigerator at 36°F to 46°F (2°C to 8°C).
Do not use TRULICITY beyond the expiration date.
If needed, each single-dose pen can be kept at room temperature, not to exceed 86°F (30°C) for a total of 14 days.
Do not freeze TRULICITY.
Do not use TRULICITY if it has been frozen.
TRULICITY must be protected from light. Storage of TRULICITY in the original carton is recommended until time of administration.
Discard the TRULICITY single-dose pen after use in a puncture-resistant container. Buy Trulicity Dulaglutide Diabetes Injection